Methyl Support
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Methyl Support

$42.00

Methylation Support | 60 capsules

Optimal Methylation Support Formula: Riboflavin, Vitamin B6, Folate, Vitamin B12

This exceptional active B vitamin supplement is designed to support healthy methylation—a vital process that impacts everything from energy and mood to detoxification and DNA repair. It is formulated to empower your body’s essential pathways for superior cardiovascular health and supports healthy methylation of estrogen, dopamine, and epinephrine, as well as processing heavy metals and environmental toxins. The folate in Methyl Protect is provided as 5-MTHF (5-methyltetrahydrofolate), which is more active and better absorbed than standard folate.

Ashwagandha

Turmeric

Vanilla Bean

Lemon Balm

Bergamot

Methyl Support

Methyl Support is a comprehensive formula designed to support optimal methylation and help maintain healthy homocysteine levels already within normal range. It features five key nutrients that are involved in homocysteine metabolism: folate as calcium folinate and Quatrefolic® for increased bioactivity; trimethylglycine; and vitamins B12, B6, and B2. These five nutrients, provided in activated forms, support enhanced methylation and overall cardiovascular health.

  • Supports Cardiovascular and Neurological Health
  • Supports the Maintenance of Healthy Homocysteine Levels Already Within Normal Range
  • Supports Healthy Methylation of Estrogen, Dopamine, Epinephrine, Heavy Metals, and Environmental Toxins

Take one capsule one to two times daily, or as directed by your healthcare professional.

Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.

Active ingredients:

  • Folic Acid (as calcium folinate and 5-methyltetrahydrofolate)
  • Trimethylglycine (as anhydrous betaine)
  • Vitamin B12 (as methylcobalamin)
  • Vitamin B6 (as pyridoxal 5’-phosphate)
  • Vitamin B2 (as riboflavin 5’-phosphate)

Other ingredients: Microcrystalline cellulose, HPMC (capsule), stearic acid, magnesium stearate, and silica.

Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.

Before use, consult with your healthcare provider if you are nursing or pregnant, have any known allergies or medical conditions, or are taking any medication.

Keep closed in a cool, dry place out of reach of children.

Deep-Dive into Ease

Cannabinoids

Cannabinoids are molecules found in the hemp flower offering functional support by interacting with the cannabinoid receptors of our body’s endocannabinoid system. CBD and CBG are known to promote relaxation, ease tension, and combat inflammation.

Ashwagandha

A powerful adaptogen  known to assist the body’s ability to manage stress, ashwagandha is considered a grounding and nourishing herb, supportive to overall well-being.

Botanicals

The essence of functional botanicals infused with organic MCT oil to support rest and restoration. Ease features essential oils of turmeric, lemon balm, lemongrass, sweet orange, and bergamot.

Ingredients

Click on an Ingredient to learn more.

GABA

Gamma-aminobutyric acid (GABA) is a key inhibitory neurotransmitter in the brain that promotes relaxation, reduces stress, and improves sleep by calming neural activity. It helps alleviate anxiety, lowers stress hormones, and may enhance mood by balancing neurotransmitter levels. GABA also supports cognitive function, reduces muscle tension, and may aid in managing conditions like epilepsy and high blood pressure. Some studies suggest it could improve immunity and gut health. While the body produces GABA naturally, supplements or GABA-rich foods (like fermented products) may provide additional benefits.

GABA

Inositol

Inositol, a naturally occurring carbohydrate-like compound, offers multiple health benefits, particularly for mental and metabolic health. Often referred to as vitamin B8, it plays a key role in cell signaling and insulin sensitivity, making it beneficial for managing PCOS, reducing insulin resistance, and improving fertility. Inositol also supports mental well-being by alleviating symptoms of anxiety, depression, and panic disorders, as it influences serotonin and dopamine activity. Additionally, it may aid in reducing binge eating and promoting healthy sleep patterns. Found in foods like fruits, beans, and grains, inositol is also available as a supplement (commonly myo-inositol or D-chiro-inositol) for targeted therapeutic effects. Its calming and metabolic benefits make it a versatile nutrient for overall wellness.

Inositol

L-theanine

L-Theanine, an amino acid primarily found in tea leaves, offers multiple benefits for mental and physical well-being. It promotes relaxation without drowsiness by increasing alpha brain waves, which enhance calm focus and reduce stress. L-Theanine also helps lower anxiety, improves sleep quality, and supports cognitive function by boosting attention, memory, and reaction time. Additionally, it may enhance the effects of caffeine when combined, providing a balanced energy boost without jitters. Some research suggests it could strengthen immunity, lower blood pressure, and provide neuroprotective benefits. Naturally present in green and black tea, L-Theanine is also available as a supplement for those seeking its calming and cognitive-enhancing effects.

L-theanine

Taurine

Taurine is a sulfur-containing amino acid that plays a vital role in various bodily functions. It supports cardiovascular health by regulating blood pressure, improving heart function, and reducing the risk of heart disease. Taurine also enhances exercise performance by reducing muscle fatigue, increasing endurance, and aiding in recovery. It supports brain health by acting as a neuroprotective agent, improving cognitive function, and potentially reducing anxiety and depression. Additionally, taurine helps regulate blood sugar levels, promotes healthy vision, and supports liver and kidney function. Found naturally in meat, fish, and dairy, taurine is also a common ingredient in energy drinks and supplements, making it beneficial for overall health and wellness.

Taurine

Magnesium

Magnesium is an essential mineral involved in over 300 biochemical reactions in the body, making it crucial for overall health. It supports muscle and nerve function, helping to reduce cramps, spasms, and restless leg syndrome. Magnesium also promotes relaxation by regulating neurotransmitters, improving sleep quality, and reducing stress and anxiety. It plays a key role in heart health by maintaining normal blood pressure and supporting cardiovascular function. Additionally, magnesium aids in energy production, bone strength, and blood sugar regulation. Some studies suggest it may help with migraines, depression, and PMS symptoms. Found in foods like leafy greens, nuts, and whole grains, magnesium is also available as a supplement to address deficiencies and enhance well-being.

Magnesium

Deep-Dive into Methyl Support

Methyl Support provides 5-methyltetrahydrofolate (active folate), pyridoxal 5’-phosphate (active B6), methylcobalamin (active B12), riboflavin 5’-phosphate (active vitamin B2), and anhydrous betaine
(trimethylglycine). These five nutrients promote the process of methylation. Methylation is the addition of a methyl group (a carbon atom with three hydrogen atoms attached) to proteins, enzymes, chemicals, DNA, or amino acids like homocysteine. It is a vital and fundamental process that takes place in many biochemical pathways
involving detoxification, cardiovascular health, neurological health, eye health, muscle health, bone health, and redox balance. Effective methylation also has roles in the biosynthesis and breakdown of catecholamines, such as epinephrine. This is an important aspect of healthy adrenal functioning.

  • Comprehensive Active B Vitamin Formula*
  • Promotes Neurological Health*
  • Supports Heart Health

Folic Acid (as calcium folinate and 5-methyltetrahydrofolate) This B vitamin has important roles in detoxification, nervous system function, breast tissue health, prenatal development, and the conversion of homocysteine back to methionine. In its active form, folic acid serves as a donor of methyl groups. Providing the combination of calcium folinate and 5-methyltetrahydrofolate (5- MTHF) allows optimal utilization of folic acid by bypassing metabolic steps to bioactivity.[1] In fact, 5-MTHF is the form into which the body must convert all other forms of folic acid before it can be used. In this formula, 5-MTHF is provided as calcium folinate and Quatrefolic®. Quatrefolic is proven to have greater stability, solubility, and bioavailability over the calcium salt forms of 5-MTHF.*

Despite research showing that folic acid and 5-MTHF have equivalent bioavailability and that supplementation with large doses of folic acid can “force” its conversion to the more active form, 5-MTHF may be the preferred form to support healthy folate status. This may be especially true in those with certain variations in folate metabolism or digestion that can affect conversion of folic acid to 5-MTHF. [2-4] Folate is stored in the red blood cells, where levels have been shown to be higher after supplementation with 5-MTHF compared to folic acid and placebo. Patients given 5 mg of 5-MTHF experienced plasma levels 700% greater than patients given folic acid.[5] In another study, authors concluded that 5-MTHF should be the primary choice of supplementation to support healthy homocysteine levels already within the normal range.*[6]

Trimethylglycine (as anhydrous betaine) Found in several tissues in humans, trimethylglycine acts as an alternative methyl donor in homocysteine metabolism. Trimethylglycine may also be a preventive agent against the activation of NF-kappaB.*[7]

Vitamin B12 (as methylcobalamin) Cyanocobalamin (the form of B12 present in many supplements) has to be converted in the liver to methylcobalamin, the form provided in Methyl Protect. B12 is another methyl donor, and studies suggest that it supports healthy homocysteine levels already within the normal range on its own and in combination with folate.*[8]

Vitamin B6 (as pyridoxal 5’-phosphate) This coenzyme form of vitamin B6 is the primary bioactive form. It is a coenzyme in approximately 100 enzymatic reactions.[9] Data from the Framingham Study showed an inverse association between homocysteine and good B6 status (as well as B12 and folate).*[10]

Vitamin B2 (as riboflavin 5’-phosphate) As the principal coenzyme form of B2, riboflavin 5’-phosphate is used in many oxidative reactions. Folate and riboflavin interact to support healthy homocysteine levels already within the normal range, possibly by maximizing the catalytic activity of the enzyme methylenetetrahydrofolate reductase (MTHFR). The effect may be unrelated to MTHFR genotype.*[11]

References
1. Venn BJ, Green TJ, Moser R, et al. Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study. Am J Clin Nutr. 2003 Mar;77(3):658-62. [PMID: 12600857]
2. Yakut M, Ustün Y, Kabaçam G, et al. Serum vitamin B(12) and folate status in patients with inflammatory bowel diseases. Eur J Intern Med. 2010 Aug;21(4):320-23. [PMID: 20603044]
3. Halsted CH, Villanueva JA, Devlin AM, et al. Folate deficiency, methionine metabolism, and alcoholic liver disease. Alcohol. 2002 Jul;27(3):169-72. [PMID: 12163145]
4. Kluijtmans LA, Van den Heuvel LP, Boers GH, et al. Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet. 1996 Jan;58(1):35-41. [PMID: 8554066]
5. Willems FF, Boers GH, Blom HJ, et al. Pharmacokinetic study on the utilisation of 5-methyltetrahydrofolate and folic acid in patients with coronary artery disease. Br J Pharmacol 2004;141:825-30. [PMID: 14769778]
6. Caruso R, Campolo J, Sedda V, et al. Effect of homocysteine lowering by 5-methyltetrahydrofolate on redox status in hyperhomocysteinemia. J Cardiovasc Pharmacol. 2006 Apr;47(4):549-55. [PMID: 16680068]
7. Go EK, Jung KJ, Kim JY, et al. Betaine suppresses proinflammatory signaling during aging: the involvement of nuclear factor-kappaB via nuclear factorinducing kinase/IkappaB kinase and mitogen-activated protein kinases. J Gerontol A Biol Sci Med Sci. 2005 Oct;60(10):1252-64. [PMID: 16282556]
8. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists’ Collaboration. BMJ. 1998 Mar;316(7135):894-98. [PMID: 9569395]
9. Strain JJ, Dowey L, Ward M, et al. B-vitamins, homocysteine metabolism and CVD. Proc Nutr Soc. 2004 Nov;63(4):597-603. [PMID: 15831132]
10. Selhub, J. 2006. The many facets of hyperhomocysteinemia: studies from the framingham cohorts. J Nutr. 2006 Jun;136(6 Suppl):1726S-30S. [PMID: 16702347]
11. Moat SJ, Ashfield-Watt PA, Powers HJ, et al. Effect of riboflavin status on the homocysteine-lowering effect of folate in relations to the MTHFR (C677T) genotype. Clin Chem. 2003 Feb;49(2):295-302. [PMID: 12560354]

How to use Kokua Creations CBD oil.

How To Use

1. Shake well before use.

2. Administer sublingually by dispensing Ease Drops under the tongue.

3. Hold for at least 60 seconds.

4. Swallow and enjoy daily support for focus, clarity, mood support, sleep, relaxation and recovery.

Consistency is key to support overall health, and the benefits of Ease Drops compound with cumulative use. Some may experience immediate effects, while others can take up to 30 days of consistent use. Individual results may vary. Ingest up to two times per day.

With growing evidence of cannabinoids’ neuroprotective properties, Ease is an essential addition to a proactive health approach. 

Strength

300mg CBG, 300mg CBD, 150mg CBG-A, 150mg CBD-A

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Methyl SupportMethyl Support
$42.00