Omega-3 Fish Oil
Omega-3 Fish Oil - Image 2

Omega-3 Fish Oil

$64.00

Omega-3 Fish Oil | 60 soft gels

This omega-3 supplement features highly concentrated fish oil with a standardized quantity of the pro-resolving mediators (PRMs) 18-HEPE, 17-HDHA, and 14-HDHA. Metabolites of PRMs, known as specialized PRMs, provide building blocks to support the natural resolution of the immune response. It positively affects the production of arachidonic acid-derived eicosanoids, supports cardiovascular health, healthy mental functioning, healthy glucose and insulin metabolism. By supplying the precursors EPA and DHA, it helps the body generate specialized proresolving lipid mediators, such as resolvins and protectins.

Ashwagandha

Turmeric

Vanilla Bean

Lemon Balm

Bergamot

Omega-3s

 Fish Oil OMEGA features MaxSimil®, a natural enzymatically enhanced monoglyceride fish oil with a 3× greater EPA/DHA absorption rate than an equivalent dose of ethyl ester fish oil. This translates to less fish oil in a smaller softgel for easy swallowing. This IFOS 5-star certified fish oil outperforms other fish oils through MaxSimil’s patented lipid absorption enhancement technology (PLATform).

  • Positively Affects the Production of Arachidonic Acid-Derived Eicosanoids
  • Supports Cardiovascular Health
  • Supports Healthy Mental Functioning
  • Supports Healthy Glucose and Insulin Metabolism
  • By Supplying the Precursors EPA and DHA, Helps the Body Generate Specialized Proresolving Lipid Mediators, Such as Resolvins and Protectins

Take one softgel daily, or use as directed by your healthcare professional.

Consult your healthcare professional prior to use. Individuals taking blood thinners or other medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.

Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.

Before use, consult with your healthcare provider if you are nursing or pregnant, have any known allergies or medical conditions, or are taking any medication.

Keep closed in a cool, dry place out of reach of children.

Deep-Dive into Ease

Cannabinoids

Cannabinoids are molecules found in the hemp flower offering functional support by interacting with the cannabinoid receptors of our body’s endocannabinoid system. CBD and CBG are known to promote relaxation, ease tension, and combat inflammation.

Ashwagandha

A powerful adaptogen  known to assist the body’s ability to manage stress, ashwagandha is considered a grounding and nourishing herb, supportive to overall well-being.

Botanicals

The essence of functional botanicals infused with organic MCT oil to support rest and restoration. Ease features essential oils of turmeric, lemon balm, lemongrass, sweet orange, and bergamot.

Ingredients

Click on an Ingredient to learn more.

GABA

Gamma-aminobutyric acid (GABA) is a key inhibitory neurotransmitter in the brain that promotes relaxation, reduces stress, and improves sleep by calming neural activity. It helps alleviate anxiety, lowers stress hormones, and may enhance mood by balancing neurotransmitter levels. GABA also supports cognitive function, reduces muscle tension, and may aid in managing conditions like epilepsy and high blood pressure. Some studies suggest it could improve immunity and gut health. While the body produces GABA naturally, supplements or GABA-rich foods (like fermented products) may provide additional benefits.

GABA

Inositol

Inositol, a naturally occurring carbohydrate-like compound, offers multiple health benefits, particularly for mental and metabolic health. Often referred to as vitamin B8, it plays a key role in cell signaling and insulin sensitivity, making it beneficial for managing PCOS, reducing insulin resistance, and improving fertility. Inositol also supports mental well-being by alleviating symptoms of anxiety, depression, and panic disorders, as it influences serotonin and dopamine activity. Additionally, it may aid in reducing binge eating and promoting healthy sleep patterns. Found in foods like fruits, beans, and grains, inositol is also available as a supplement (commonly myo-inositol or D-chiro-inositol) for targeted therapeutic effects. Its calming and metabolic benefits make it a versatile nutrient for overall wellness.

Inositol

L-theanine

L-Theanine, an amino acid primarily found in tea leaves, offers multiple benefits for mental and physical well-being. It promotes relaxation without drowsiness by increasing alpha brain waves, which enhance calm focus and reduce stress. L-Theanine also helps lower anxiety, improves sleep quality, and supports cognitive function by boosting attention, memory, and reaction time. Additionally, it may enhance the effects of caffeine when combined, providing a balanced energy boost without jitters. Some research suggests it could strengthen immunity, lower blood pressure, and provide neuroprotective benefits. Naturally present in green and black tea, L-Theanine is also available as a supplement for those seeking its calming and cognitive-enhancing effects.

L-theanine

Taurine

Taurine is a sulfur-containing amino acid that plays a vital role in various bodily functions. It supports cardiovascular health by regulating blood pressure, improving heart function, and reducing the risk of heart disease. Taurine also enhances exercise performance by reducing muscle fatigue, increasing endurance, and aiding in recovery. It supports brain health by acting as a neuroprotective agent, improving cognitive function, and potentially reducing anxiety and depression. Additionally, taurine helps regulate blood sugar levels, promotes healthy vision, and supports liver and kidney function. Found naturally in meat, fish, and dairy, taurine is also a common ingredient in energy drinks and supplements, making it beneficial for overall health and wellness.

Taurine

Magnesium

Magnesium is an essential mineral involved in over 300 biochemical reactions in the body, making it crucial for overall health. It supports muscle and nerve function, helping to reduce cramps, spasms, and restless leg syndrome. Magnesium also promotes relaxation by regulating neurotransmitters, improving sleep quality, and reducing stress and anxiety. It plays a key role in heart health by maintaining normal blood pressure and supporting cardiovascular function. Additionally, magnesium aids in energy production, bone strength, and blood sugar regulation. Some studies suggest it may help with migraines, depression, and PMS symptoms. Found in foods like leafy greens, nuts, and whole grains, magnesium is also available as a supplement to address deficiencies and enhance well-being.

Magnesium

Deep-Dive into Fish Oil OMEGA

The MaxSimil PLATform is a novel monoglyceride delivery system that enhances absorption of lipid-based and lipid-soluble nutraceutical and food ingredients. This technology has been applied to this fish oil formula in order to create a unique vehicle by which to deliver EPA and DHA. Due to the fact that monoglyceride oils are intrinsically emulsifiers and are, by nature, in a readily absorbable form, they can bypass the body’s normal fat digestion process. These qualities make this Fish Oil Omega supplement an excellent method for delivering omega-3 fatty acids, especially to individuals with digestive, pancreatic, or gall bladder challenges. Studies show that MaxSimil fish oils (FO) have three times (300%) greater absorption of EPA and DHA compared to other leading fish oils.*[1-3]

This Kokua formula is made using proprietary MaxSimil compositions containing monoglyceride FO with no additional ingredients, carriers, or excipients. Each fish-gelatin softgel is enteric-coated, and every batch of fish oil is IFOS five-star certified to ensure the world’s highest standards for purity, potency, and freshness. The fish oil is non-GMO, certified sustainable from Scandinavia, and antibiotic-free. Additionally, it is eco-friendly because the greater absorption of EPA and DHA ultimately means that fewer grams of fish oil need to be harvested for the same benefit.

In Vitro and In Vivo Animal Studies
The ability of MaxSimil-enhanced EPA and DHA to positively influence growth inhibition and apoptosis in colorectal, breast, lung, and prostate diseased cell lines was first demonstrated in a series of in vitro studies.[4-6] Researchers subsequently set out to demonstrate efficacy in animal models after oral administration. In three separate animal models, MaxSimil EPA and DHA forms showed superior activity on diseased cell-line growth inhibition and cytokine production when compared to control, corn oil, krill oil, or the parent forms ethyl ester (EE) EPA and ethyl ester (EE) DHA.[4,7,8] These in vivo animal studies proved that orally supplemented MaxSimil EPA and DHA were well-absorbed and bioactive. Researchers postulated that the observed superior effects of MaxSimil EPA and DHA forms were the result of enhanced absorption, and they set out to prove this hypothesis.*

Preclinical Bioavailability Studies
The in vivo pharmacokinetic studies in rodents involved a comparison between MaxSimil DHA FO and its parent EE DHA FO and an analysis of blood concentrations of DHA over time. The doses used were equivalent to human doses of 3 g/day and 30 g/day; the latter was included primarily to investigate toxicity at high doses. Researchers found that MaxSimil DHA FO had a three times (3x) higher peak concentration (6% versus 2%), a 3x higher saturation potential at the high dose (10% versus 3%), and a 3x higher absorption rate (at a 3 g/day equivalent human dose) than its parent DHA FO. No toxicity was observed at either dose level.[1,2] This research demonstrated superior bioavailability and presumably better exposure of cells to DHA.*

A Note About Resolvins and Other EPA and DHA Metabolites
Specialized proresolving lipid mediators, such as resolvins, protectins, and maresins, are EPA and DHA metabolites naturally produced in vivo through enzymatic conversion of EPA and DHA. These mediators aid the body’s “clean-up” response to the arachidonic acid cascade.[13] Rather than supplying a single molecule or metabolite, which would mirror the pharmaceutical model, Kokua fish oils provide all the benefits of EPA and DHA as well as the expected and desirable benefits of their metabolites.*

References
1. Unpublished, internal data. Ingenutra.
2. Fortin S, inventor; Centre de Recherche sur les Biotechnologies Marines, assignee. Compositions comprising polyunsaturated fatty acid monoglycerides or derivatives thereof and uses thereof. US patent 8,198,324. June 12, 2012.
3. MaxSimil Patented Lipid Absorption Technology Clinical Study Report: MaxSimil® 3020 Omega-3. Sherbrooke (Québec), Canada: Ingenutra; 2015. [Unpublished, internal data]
4. Morin C, Rousseau É, Fortin S. Anti-proliferative effects of a new docosapentaenoic acid monoacylglyceride in colorectal carcinoma cells. Prostaglandins Leukot Essent Fatty Acids. 2013 Sep;89(4):203-13. [PMID: 23932824]
5. Fortin S, inventor; Centre de Recherche sur les Biotechnologies Marines, assignee. Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof. US patent 8,119,690. February 21, 2012.
6. Fortin S, inventor; Centre de Recherche sur les Biotechnologies Marines, assignee. Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof. US patent 8,329,747. December 11, 2012.
7. Morin C, Blier PU, Fortin S. Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model. Arthritis Res Ther. 2015 May 29;17:142. [PMID: 26022389]
8. Morin C, Fortin S, Cantin AM, et al. Docosahexaenoic acid derivative prevents inflammation and hyperreactivity in lung: implication of PKC-Potentiated inhibitory protein for heterotrimeric myosin light chain phosphatase of 17 kD in asthma. Am J Respir Cell Mol Biol. 2011 Aug;45(2):366-75. [PMID: 21057106]
9. Morin C, Fortin S, Cantin AM, et al. MAG-EPA resolves lung inflammation in an allergic model of asthma. Clin Exp Allergy. 2013 Sep;43(9):1071-82. [PMID: 23957343]
10. Morin C, Cantin AM, Rousseau É, et al. Pro-resolving action of MAG-DHA in lung inflammatory models related to cystic fibrosis. Am J Respir Cell Mol Biol. 2015 Oct;53(4):574-83. [PMID: 25781052]
11. Morin C, Fortin S, Rousseau É. New omega-3 derivatives reduce airway inflammation and prevent rho-kinase activation in an allergic model of asthma. J Aller Ther. 2012;3(S1):003. doi:10.4172/2155-6121.S1-003.
12. Morin C, Rousseau E, Blier PU, et al. Effect of docosahexaenoic acid monoacylglyceride on systemic hypertension and cardiovascular dysfunction. Am J Physiol Heart Circ Physiol. 2015 Jul 1;309(1):H93-H102. [PMID: 25910811]
13. Weylandt KH, Chiu CY, Gomolka B, et al. Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. Prostaglandins Other Lipid Mediat. 2012 Mar;97(3-4):73-82. [PMID: 22326554]

How to use Kokua Creations CBD oil.

How To Use

1. Shake well before use.

2. Administer sublingually by dispensing Ease Drops under the tongue.

3. Hold for at least 60 seconds.

4. Swallow and enjoy daily support for focus, clarity, mood support, sleep, relaxation and recovery.

Consistency is key to support overall health, and the benefits of Ease Drops compound with cumulative use. Some may experience immediate effects, while others can take up to 30 days of consistent use. Individual results may vary. Ingest up to two times per day.

With growing evidence of cannabinoids’ neuroprotective properties, Ease is an essential addition to a proactive health approach. 

Strength

300mg CBG, 300mg CBD, 150mg CBG-A, 150mg CBD-A

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Omega-3 Fish OilOmega-3 Fish Oil
$64.00